Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44556 | 0.93 | GSK3B (0.43) | GSK3B | |
| SCHEMBL44251 | 0.87 | GSK3B (0.48) | CYP2C9CYP2C19GSK3BHPGDSHPGD | |
| SCHEMBL43952 | 0.84 | SMPD1 (0.36) | MAPTGSK3BPOLBLMNA | |
| SCHEMBL44541 | 0.84 | PDE4B (0.41) | ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL44296 | 0.83 | MARK3 (0.39) | MAPTPOLBLMNAKMT2A | |
| SCHEMBL44205 | 0.83 | SMPD1 (0.35) | HPGD | |
| SCHEMBL44632 | 0.82 | LMNA (0.36) | MAPTPOLBLMNA | |
| SCHEMBL44454 | 0.82 | CHEK2 (0.36) | MAPTGSK3BPOLBLMNA | |
| SCHEMBL44225 | 0.81 | MAPT (0.50) | HSD17B10ALDH1A1CYP1A2CYP3A4MAPT | |
| SCHEMBL44473 | 0.80 | GRM5 (0.40) | MAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |