Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961892 | 0.88 | UCHL1 (0.48) | UCHL1HTRA1F10SYKAR | |
| SCHEMBL4492699 | 0.80 | F10 (0.41) | F10SYKKMT2A | |
| SCHEMBL3696448 | 0.80 | MEN1 (0.36) | F10SYKGPR119NR1H2MEN1 | |
| SCHEMBL4497009 | 0.79 | F10 (0.51) | F10 | |
| SCHEMBL4598458 | 0.77 | F10 (0.35) | F10SYKMEN1KMT2A | |
| SCHEMBL4599382 | 0.77 | HDAC8 (0.35) | F10SYKMEN1KMT2A | |
| SCHEMBL4496265 | 0.77 | F10 (0.56) | F10 | |
| SCHEMBL4598659 | 0.76 | SYK (0.34) | F10SYKGPR119MEN1KMT2A | |
| SCHEMBL13675146 | 0.73 | F10 (0.45) | F10CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL4442250 | 0.71 | F10 (0.62) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601752-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-20070112001-A1 | Pyrrolidine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112001-A1 | Pyrrolidine derivatives | F12, F2, F11 | UCHL1 3309/4885HTRA1 215/4885F10 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.