Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24104953 | 0.75 | TAAR1 (0.39) | SORT1TAAR1LMNACYP1A2ADRA2A | |
| SCHEMBL6604537 | 0.67 | SORT1 (0.46) | SORT1LMNACYP1A2DHFRCALM1 | |
| SCHEMBL11685926 | 0.67 | DHFR (0.52) | SORT1CYP1A2DHFRCALM1DAO | |
| SCHEMBL4462633 | 0.67 | AXL (0.50) | SORT1PARP1ARTAAR1LMNA | |
| SCHEMBL31541476 | 0.64 | SORT1 (0.47) | SORT1PARP1ARLMNACYP1A2 | |
| SCHEMBL28984179 | 0.64 | TAAR1 (0.46) | SORT1PARP1ARTAAR1LMNA | |
| SCHEMBL10733624 | 0.63 | CALM1 (0.50) | SORT1PARP1ARCYP1A2CALM1 | |
| SCHEMBL11963994 | 0.63 | SORT1 (1.00) | SORT1PARP1ARTAAR1LMNA | |
| SCHEMBL2479409 | 0.63 | CALM1 (0.44) | SORT1PARP1ARTAAR1LMNA | |
| SCHEMBL31411865 | 0.62 | SORT1 (0.49) | SORT1PARP1ARTAAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579481-B2 | Method of making imidazole-2-ones and 2-thiones | ALLERGAN, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070197795-A1 | METHOD OF MAKING IMIDAZOLE-2-ONES AND 2-THIONES | ALLERGAN, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007025271-A1 | METHOD OF MAKING IMIDAZOLE-2-ONES AND 2-THIONES | ALLERGAN, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| US-4426446-A | Leucocyte adherence inhibition assay for detection of cancer | HOFFMANN-LA ROCHE INC. (US) | 1984-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197795-A1 | METHOD OF MAKING IMIDAZOLE-2-ONES AND 2-THIONES | TPMT, TST, CPS1 | SORT1 4266/4885PARP1 3286/4885AR 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.