Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 8/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10563802 | 0.98 | KDM4E (0.48) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL172248 | 0.79 | CYP19A1 (0.61) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL28238914 | 0.77 | KDM4E (0.51) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL171844 | 0.76 | CTSD (0.52) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL2607440 | 0.75 | ALDH1A1 (0.55) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL13826029 | 0.75 | KDM4E (0.49) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL13351524 | 0.75 | ALDH1A1 (0.66) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL30172357 | 0.74 | ESR2 (0.53) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL13376084 | 0.73 | HTT (0.56) | KDM4EHPGDHSD17B10ALDH1A1HTT | |
| SCHEMBL29470569 | 0.73 | CTSD (0.50) | KDM4EHPGDHSD17B10ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421076-B1 | HYDRATES OF OPTIONALLY SUBSTITUTED 2-(2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLES AND METHOD FOR THE PRODUCTION THEREOF | GRUENENTHAL GMBH (DE) | 2007-10-10 | — | — | EP | claimed |
| US-7557218-B2 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2009-07-07 | — | — | US | disclosed |
| US-7557218-B2 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2009-07-07 | — | — | US | disclosed |
| US-20080269497-A1 | Hydrates of Optionally Substituted 2-(2-Pyridinyl) Methylthio-1H-Benzimidazoles and Process for the Production Thereof | GRUNENTHAL GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| US-20080269497-A1 | Hydrates of Optionally Substituted 2-(2-Pyridinyl) Methylthio-1H-Benzimidazoles and Process for the Production Thereof | GRUNENTHAL GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
| US-7435825-B2 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2008-10-14 | — | — | US | disclosed |
| US-7435825-B2 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2008-10-14 | — | — | US | disclosed |
| US-20040158072-A1 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2004-08-12 | — | — | US | disclosed |
| US-20040158072-A1 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | GRUNENTHAL GMBH (DE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040158072-A1 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof | BHMT2, H1-4, TBCB | KDM4E 1284/4885HPGD 417/4885HSD17B10 1929/4885 |
| US-20080269497-A1 | Hydrates of Optionally Substituted 2-(2-Pyridinyl) Methylthio-1H-Benzimidazoles and Process for the Production Thereof | PIR, TBCB, AZI2 | KDM4E 1095/4885HPGD 726/4885HSD17B10 2650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.