Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512472 | 0.81 | NPC1 (0.43) | AKR1C3AKR1C2PTGS1AKR1C1KDM4E | |
| SCHEMBL7064360 | 0.76 | KDM4E (0.52) | AKR1C3AKR1C2KDM4EALDH1A1NPC1 | |
| SCHEMBL2945200 | 0.76 | ALDH1A1 (0.67) | KDM4EALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL28532626 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL31055812 | 0.76 | KDM4E (0.52) | AKR1C3AKR1C2KDM4EALDH1A1NPC1 | |
| SCHEMBL621720 | 0.75 | KDM4E (0.58) | KDM4EALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL635539 | 0.75 | PTGS1 (0.52) | AKR1C3AKR1C2PTGS1KDM4EALDH1A1 | |
| SCHEMBL24991971 | 0.74 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1AKR1C1KDM4E | |
| SCHEMBL3043390 | 0.74 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1AKR1C1KDM4E | |
| SCHEMBL505820 | 0.74 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1AKR1C1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504507-B2 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-03-17 | — | — | US | disclosed |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | MKI67, MCL1, CCNI | AKR1C3 1918/4885AKR1C2 1642/4885PTGS1 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.