Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12167116 | 0.88 | KDM4E (0.76) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL28532626 | 0.84 | KDM4E (0.52) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL7064360 | 0.84 | KDM4E (0.52) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL31055812 | 0.84 | KDM4E (0.52) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL621720 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL1574317 | 0.82 | KDM4E (0.80) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL5234472 | 0.80 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL5208343 | 0.80 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL635539 | 0.80 | PTGS1 (0.52) | ALDH1A1KDM4EHPGDPOLBHSD17B10 | |
| SCHEMBL16047470 | 0.79 | ALDH1A1 (0.73) | ALDH1A1POLBHSD17B10SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970125-B1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2018-07-18 | — | — | EP | disclosed |
| US-9956213-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2018-05-01 | — | — | US | disclosed |
| US-20170312263-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2017-11-02 | — | — | US | disclosed |
| US-9675605-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2017-06-13 | — | — | US | disclosed |
| US-20160074377-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE, LLC | 2016-03-17 | — | — | US | disclosed |
| EP-2970125-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | Dart Neuroscience (Cayman) Ltd (KY) | 2016-01-20 | — | — | EP | disclosed |
| US-9150572-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-10-06 | — | — | US | disclosed |
| US-9102674-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-08-11 | — | — | US | disclosed |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE LLC | 2014-10-23 | — | — | US | disclosed |
| WO-2014158916-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | DART NEUROSCIENCE, LLC (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-1902050-A1 | OXAZOLIDINONE DERIVATIVES AND USE THEREOF AS ANTIBIOTICS | FERRER INTERNACIONAL, S.A. (ES) | 2008-03-26 | — | — | EP | disclosed |
| EP-1372654-A4 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SMITHKLINE BEECHAM CORP (US) | 2007-10-03 | — | — | EP | disclosed |
| EP-1745784-A1 | Oxazolidinone derivatives and use thereof as antibiotics | FERRER INTERNACIONAL, S.A. (ES) | 2007-01-24 | — | — | EP | disclosed |
| EP-1745784-A1 | Oxazolidinone derivatives and use thereof as antibiotics | FERRER INTERNACIONAL, S.A. (ES) | 2007-01-24 | — | — | EP | disclosed |
| WO-2007000432-A1 | OXAZOLIDINONE DERIVATIVES AND USE THEREOF AS ANTIBIOTICS | FERRER INTERNACIONAL, S. A. (ES) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007000432-A1 | OXAZOLIDINONE DERIVATIVES AND USE THEREOF AS ANTIBIOTICS | FERRER INTERNACIONAL, S. A. (ES) | 2007-01-04 | — | — | WO | disclosed |
| US-7087758-B2 | Quinoline inhibitors of hyaki and hyak3 kinases | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-08 | — | — | US | disclosed |
| US-20050043352-A1 | Quinoline inhibitors of hyaki and hyak3 kinases | SMITHKLINE BEECHAM CORPORATION | 2005-02-24 | — | — | US | disclosed |
| EP-1372654-A2 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SmithKline Beecham Corporation (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081728-A2 | QUINOLINE INHIBITORS OF HYAK1 AND HYAK3 KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160074377-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | ALDH1A1 819/4885KDM4E 1441/4885HPGD 2206/4885 |
| US-20050043352-A1 | Quinoline inhibitors of hyaki and hyak3 kinases | HIPK3, HIPK1, HYPK | ALDH1A1 3983/4885KDM4E 2924/4885HPGD 1852/4885 |
| US-20170312263-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | ALDH1A1 841/4885KDM4E 1487/4885HPGD 2202/4885 |
| US-20140315944-A1 | SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS | MAOB, MAOA, PNMT | ALDH1A1 841/4885KDM4E 1487/4885HPGD 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.