Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 3/20 | 0.32 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504420 | 0.89 | KIF11 (0.46) | KIF11ROCK2EEF2KKHKPDE6D | |
| SCHEMBL4500235 | 0.89 | GHSR (0.35) | KIF11ROCK2EEF2K | |
| SCHEMBL4505256 | 0.84 | KIF11 (0.44) | KIF11ROCK2EEF2KMAP1LC3BDHODH | |
| SCHEMBL4484483 | 0.78 | KIF11 (0.46) | KIF11ROCK2EEF2KKHKMAP1LC3B | |
| SCHEMBL4484748 | 0.73 | KIF11 (0.63) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4493304 | 0.72 | KIF11 (0.60) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4502944 | 0.71 | KIF11 (0.42) | KIF11ROCK2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4511153 | 0.71 | KIF11 (0.45) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 | |
| SCHEMBL4500793 | 0.70 | KIF11 (0.42) | KIF11ROCK2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4500050 | 0.70 | KIF11 (0.52) | KIF11MAP1LC3BCYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476743-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| EP-1558588-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20060189671-A1 | Compounds, compositions, and methods | CYTOKINETICS, INCORPORATED | 2006-08-24 | — | — | US | disclosed |
| EP-1558588-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004032840-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189671-A1 | Compounds, compositions, and methods | TK1, TK2, TYMP | KIF11 801/4885ROCK2 2250/4885SLC6A2 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.