Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512591 | 0.84 | TSHR (0.40) | TSHRHSD17B10CYP19A1SIGMAR1NSD2 | |
| SCHEMBL4511731 | 0.83 | CYP19A1 (0.43) | TSHRHSD17B10CYP19A1MMP12MMP13 | |
| SCHEMBL4509219 | 0.80 | MMP2 (0.53) | CYP19A1MMP13 | |
| SCHEMBL8010118 | 0.75 | TSHR (0.54) | TSHRHSD17B10CYP19A1SIGMAR1CYP2A6 | |
| SCHEMBL5338091 | 0.74 | KMT2A (0.45) | TSHRHSD17B10SIGMAR1NSD2CYP2A6 | |
| SCHEMBL20597769 | 0.73 | SNCA (0.51) | SIGMAR1NSD2CYP2A6SAE1UBA2 | |
| SCHEMBL27689063 | 0.73 | TDP1 (0.51) | SIGMAR1 | |
| SCHEMBL81846 | 0.73 | TSHR (0.55) | TSHRHSD17B10CYP19A1CYP2A6MMP12 | |
| SCHEMBL2959480 | 0.71 | TSHR (0.58) | TSHRHSD17B10CYP19A1CYP2A6MMP12 | |
| SCHEMBL1526065 | 0.71 | MAPT (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099162-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20080319198-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080249086-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | US | disclosed |
| US-20080207899-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| US-20080146812-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
| US-7354917-B2 | Oxabispidine compounds and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2008-04-08 | — | — | US | disclosed |
| US-20070259864-A1 | Novel Oxabispidine Compounds and Their Use in the Treatment of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099162-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
| US-20080207899-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
| US-20070259864-A1 | Novel Oxabispidine Compounds and Their Use in the Treatment of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
| US-20080146812-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
| US-20080319198-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
| US-20080249086-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | TSHR 1565/4885HSD17B10 2992/4885CYP19A1 1988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.