Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506545 | 0.92 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTNPC1RAB9AHPGD | |
| SCHEMBL4492357 | 0.89 | ALDH1A1 (0.58) | SMN1; SMN2MAPTNPC1RAB9AHPGD | |
| SCHEMBL4518579 | 0.88 | ALDH1A1 (0.62) | SMN1; SMN2MAPTNPC1RAB9AHPGD | |
| SCHEMBL4504035 | 0.88 | ALDH1A1 (0.59) | SMN1; SMN2MAPTHPGDALDH1A1LMNA | |
| SCHEMBL4504870 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTRAB9AHPGDALDH1A1 | |
| SCHEMBL4509888 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2MAPTNPC1RAB9AHPGD | |
| SCHEMBL4506087 | 0.85 | ALDH1A1 (0.68) | SMN1; SMN2MAPTHPGDALDH1A1LMNA | |
| SCHEMBL4502685 | 0.84 | ALDH1A1 (0.56) | SMN1; SMN2MAPTRAB9AHPGDALDH1A1 | |
| SCHEMBL4515696 | 0.84 | ALDH1A1 (0.56) | SMN1; SMN2MAPTHPGDALDH1A1LMNA | |
| SCHEMBL4516512 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2MAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | SMN1; SMN2 2075/4885MAPT 4022/4885NPC1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.