Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15602070 | 0.75 | ALDH1A1 (0.50) | LMNANPSR1NR4A2CREBBPSLC22A6 | |
| SCHEMBL30171037 | 0.75 | ATM (0.54) | LMNANPSR1PBRM1ALDH1A1KMT2A | |
| SCHEMBL4212837 | 0.75 | ATM (0.54) | LMNANPSR1PBRM1ALDH1A1KMT2A | |
| SCHEMBL27462408 | 0.73 | ALDH1A1 (0.52) | LMNANPSR1PBRM1ALDH1A1KMT2A | |
| SCHEMBL8835797 | 0.73 | LMNA (0.48) | LMNANPSR1NR4A2CREBBPSLC22A6 | |
| SCHEMBL4666381 | 0.73 | ALDH1A1 (0.56) | LMNANPSR1PBRM1ALDH1A1KMT2A | |
| SCHEMBL7970007 | 0.72 | LMNA (0.57) | LMNANPSR1NR4A2CREBBPSLC22A6 | |
| SCHEMBL27945072 | 0.72 | NR4A2 (0.53) | LMNANPSR1NR4A2CREBBPSLC22A6 | |
| Hydrochloric Acid SCHEMBL27974088 | 0.71 | NR4A2 (0.51) | LMNANPSR1NR4A2CREBBPSLC22A6 | |
| SCHEMBL9185273 | 0.70 | ALDH1A1 (0.54) | LMNANPSR1NR4A2CREBBPSLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-03 | — | — | US | disclosed |
| US-7579350-B2 | 5-Isobutyl-6-4-isopropyl-4,5-dihydro-oxazol-2-yl)-pyridazin-3-yl]-piperidin-1-yl-methanone; mimetics of functionalized pyridazine derivatives having low molecular weight; alpha-helical binding ligands of natural receptors such as those of the peptide galanin or the protein Bcl | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-08-25 | — | — | US | disclosed |
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205728-A1 | Novel scaffolds for beta-helix mimicry | HRH1, HEATR1, HSPH1 | LMNA 2255/4885NPSR1 481/4885NR4A2 83/4885 |
| US-20090298835-A1 | NOVEL SCAFFOLDS FOR ALPHA-HELIX MIMICRY | HRH1, HEATR1, PLEKHA1 | LMNA 2229/4885NPSR1 417/4885NR4A2 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.