Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491363 | 0.92 | ESR1 (0.43) | PTGESESR1KMT2AMEN1ATM | |
| SCHEMBL4506325 | 0.92 | PTGES (0.56) | PTGESESR1KMT2AMEN1ESR2 | |
| SCHEMBL4505853 | 0.87 | PTGES (0.46) | PTGESESR1KMT2AMEN1ATM | |
| SCHEMBL4509210 | 0.85 | CA1 (0.43) | ESR1ALDH1A1GLO1CA12CA1 | |
| SCHEMBL4497044 | 0.84 | PTGES (0.45) | PTGESESR1ALDH1A1NPC1RAB9A | |
| SCHEMBL4508410 | 0.82 | PTGES (0.41) | PTGESESR1KMT2AMEN1NPC1 | |
| SCHEMBL4494785 | 0.81 | ESR1 (0.49) | PTGESESR1ATMNPC1RAB9A | |
| SCHEMBL4519118 | 0.81 | PTGES (0.50) | PTGESKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL4503637 | 0.81 | PTGES (0.40) | PTGESESR1KMT2AMEN1GLO1 | |
| SCHEMBL4506540 | 0.81 | PTGES (0.40) | PTGESESR1KMT2AMEN1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090234014-A1 | Naphthalene-Disulfonamides Useful for the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-1934173-A1 | NAPHTHALENE-DISULFONAMIDES USEFUL FOR THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042817-A1 | NAPHTHALENE-DISULFONAMIDES USEFUL FOR THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234014-A1 | Naphthalene-Disulfonamides Useful for the Treatment of Inflammation | AREG, PRSS12, CXCL8 | PTGES 41/4885ESR1 1760/4885KMT2A 4670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.