Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 6/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4505112 | 0.93 | GRM5 (0.45) | PDK1GRM5DRD4NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL4508112 | 0.93 | DRD4 (0.44) | PDK1GRM5DRD4TRPV1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4505929 | 0.93 | CYP1A2 (0.48) | PDK1GRM5DRD4NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL4516141 | 0.92 | PHGDH (0.40) | PDK1GRM5MAPK1TRPV1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4504324 | 0.92 | PHGDH (0.46) | PDK1NPC1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4495237 | 0.90 | TRPV1 (0.40) | PDK1GRM5DRD4TRPV1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4515416 | 0.90 | GRM5 (0.43) | PDK1GRM5DRD4TRPV1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4493583 | 0.90 | GRM5 (0.41) | PDK1GRM5DRD4NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL4510447 | 0.90 | RBP4 (0.46) | TRPV1PHGDH | |
| Trifluoroacetic Acid SCHEMBL4505237 | 0.90 | TRPV1 (0.39) | PDK1GRM5TRPV1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | PDK1 663/4885GRM5 4026/4885MAPK1 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.