Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 5/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | CCR3 | P51677 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4501514 | 0.92 | PDK1 (0.47) | PHGDHPDK1GRM5TRPV1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL4508112 | 0.92 | DRD4 (0.44) | PHGDHPDK1GRM5CCR3TRPV1 | |
| Trifluoroacetic Acid SCHEMBL4504324 | 0.91 | PHGDH (0.46) | PHGDHPDK1PDE2A | |
| Trifluoroacetic Acid SCHEMBL4505112 | 0.87 | GRM5 (0.45) | PHGDHPDK1GRM5CCR3ABL1 | |
| Trifluoroacetic Acid SCHEMBL4505237 | 0.87 | TRPV1 (0.39) | PHGDHPDK1EPHA2GRM5TRPV1 | |
| Trifluoroacetic Acid SCHEMBL4505929 | 0.87 | CYP1A2 (0.48) | PHGDHPDK1GRM5 | |
| Trifluoroacetic Acid SCHEMBL4493583 | 0.86 | GRM5 (0.41) | PHGDHPDK1GRM5ABL1 | |
| Trifluoroacetic Acid SCHEMBL4506794 | 0.85 | DRD4 (0.42) | PHGDHPDK1GRM5PDE2A | |
| Trifluoroacetic Acid SCHEMBL4503751 | 0.85 | DRD4 (0.45) | PHGDHEPHA2GRM5TRPV1 | |
| Trifluoroacetic Acid SCHEMBL4495237 | 0.84 | TRPV1 (0.40) | PHGDHPDK1GRM5CCR3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | PHGDH 1406/4885PDK1 663/4885EPHA2 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.