Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.34 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461891 | 0.86 | HDAC1 (0.38) | TOP2ATOP2BDHFRCYP11B1CYP11B2 | |
| SCHEMBL4463068 | 0.81 | ALDH1A1 (0.50) | TOP2ATOP2BDHFRCYP11B1CYP11B2 | |
| SCHEMBL4566331 | 0.80 | TOP2A (0.40) | TOP2ATOP2BDHFRCYP11B1CYP11B2 | |
| SCHEMBL4316162 | 0.80 | MPO (0.42) | TOP2ATOP2BCYP11B1CYP11B2HTR3A | |
| SCHEMBL4570057 | 0.71 | NPSR1 (0.59) | HDAC1POLBMAPTGAAHPGD | |
| SCHEMBL4495172 | 0.69 | GAA (0.44) | POLBMAPTGAAHPGDKDM4E | |
| SCHEMBL4502590 | 0.69 | MAPT (0.39) | MAPTGAAHPGDPIM1CLK2 | |
| SCHEMBL30615630 | 0.69 | AURKA (0.56) | TOP2ATOP2BMAPT | |
| SCHEMBL4504602 | 0.68 | MAPT (0.51) | POLBMAPTGAAKDM4EALDH1A1 | |
| SCHEMBL4465236 | 0.68 | KDM4E (0.50) | MAPTGAAHPGDCYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | MPO, XDH, EPX | TOP2A 842/4885TOP2B 990/4885DHFR 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.