SCHEMBL4504262

SCHEMBL4504262

Cn1c(=O)c(C(=O)C=Cc2cccc(C(=O)NCC(=O)O)c2)c(O)c2cccnc21

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 2/20 0.45
HIF1A Q16665 17/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4504253 1.00 EGLN1 (0.45) EGLN1HIF1A
SCHEMBL4516552 0.92 P4HB (0.37) EGLN1HIF1A
SCHEMBL4516547 0.92 P4HB (0.37) EGLN1HIF1A
SCHEMBL4510487 0.88 KDM4E (0.39)
SCHEMBL4510491 0.88 KDM4E (0.39)
SCHEMBL4520585 0.83 NQO1 (0.42)
SCHEMBL4520592 0.83 NQO1 (0.42)
SCHEMBL13818111 0.83 EGLN1 (0.45) EGLN1HIF1A
SCHEMBL2576889 0.81 EGLN1 (0.59) EGLN1HIF1A
SCHEMBL2284349 0.79 NPC1 (0.42) EGLN1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143368-A1 Use of Cinnamoyl Compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-04 US disclosed
EP-1857104-A1 USE OF CINNAMOYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143368-A1 Use of Cinnamoyl Compound COL2A1, COL1A1, SMAD2 EGLN1 208/4885HIF1A 196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.