Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 8/20 | 0.41 |
| ▸ | PPARA | Q07869 | 7/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL113983 | 0.99 | CXCR2 (0.43) | CXCR2CA1CA2CA9PPARG | |
| Biphenyl SCHEMBL710434 | 0.97 | CXCR2 (0.42) | CXCR2CA1CA2CA9PPARG | |
| SCHEMBL4535172 | 0.91 | CXCR2 (0.48) | CXCR2CXCR1PTGS1PTGS2LMNA | |
| Hydrogen Sulfide SCHEMBL27492503 | 0.90 | CXCR2 (0.47) | CXCR2CXCR1PTGS1PTGS2LMNA | |
| SCHEMBL24360466 | 0.79 | CA2 (0.62) | CXCR2CA1CA2CA9CXCR1 | |
| SCHEMBL5532552 | 0.79 | CA2 (0.62) | CXCR2CA1CA2CA9CXCR1 | |
| Biphenyl SCHEMBL4512202 | 0.79 | BACE1 (0.51) | CXCR2CA1CA2CA9PPARG | |
| Biphenyl SCHEMBL4521706 | 0.79 | CA2 (0.49) | CXCR2CA1CA2CA9PPARG | |
| SCHEMBL8687304 | 0.78 | CXCR2 (0.45) | CXCR2CA2PPARGPPARACXCR1 | |
| SCHEMBL8687306 | 0.78 | CXCR2 (0.45) | CXCR2CA2PPARGPPARACXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598018-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-10-06 | — | — | US | claimed |
| US-7291442-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-11-06 | — | — | US | claimed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | claimed |
| US-7611823-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7524611-B2 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20080187862-A1 | New photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC. | 2008-08-07 | — | — | US | disclosed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | disclosed |