Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP16 | P51512 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL115843 | 0.98 | BACE1 (0.53) | BACE1CA1CA2CA9NFE2L2 | |
| Biphenyl SCHEMBL713552 | 0.97 | BACE1 (0.51) | BACE1CA1CA2CA9NFE2L2 | |
| Iodide SCHEMBL1859836 | 0.91 | CA1 (0.55) | BACE1CA1CA2CA9NFE2L2 | |
| SCHEMBL1997269 | 0.89 | CA1 (0.57) | BACE1CA1CA2CA9NFE2L2 | |
| SCHEMBL24360466 | 0.87 | CA2 (0.62) | BACE1CA1CA2CA9KMT2A | |
| Hydrogen Sulfide SCHEMBL5082548 | 0.87 | CA1 (0.55) | BACE1CA1CA2CA9NFE2L2 | |
| SCHEMBL5532552 | 0.87 | CA2 (0.62) | BACE1CA1CA2CA9KMT2A | |
| Biphenyl SCHEMBL4521706 | 0.86 | CA2 (0.49) | CA1CA2CA9PPARGSMN1; SMN2 | |
| Biphenyl SCHEMBL28551760 | 0.85 | CA1 (0.53) | CA1CA2CA9NFE2L2PPARG | |
| Iodobenzene SCHEMBL2903737 | 0.85 | NFE2L2 (0.46) | BACE1CA1CA2CA9NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598018-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-10-06 | — | — | US | claimed |
| US-7291442-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-11-06 | — | — | US | claimed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | claimed |
| US-7611823-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7524611-B2 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20080187862-A1 | New photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC. | 2008-08-07 | — | — | US | disclosed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | disclosed |