SCHEMBL45138

SCHEMBL45138

NC(=O)c1ccc(C(=O)NO)c(C(N)=O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLAU P00749 2/20 0.44
HDAC6 Q9UBN7 7/20 0.41
PARP1 P09874 2/20 0.41
HDAC1 Q13547 4/20 0.41
HDAC3 O15379 2/20 0.40
NCOR2 Q9Y618 1/20 0.40
LCK P06239 1/20 0.40
HDAC8 Q9BY41 3/20 0.39
HDAC2 Q92769 2/20 0.39
DGAT1 O75907 1/20 0.39
KDM4E B2RXH2 1/20 0.38
MPO P05164 1/20 0.38
GAA P10253 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HIF1A Q16665 1/20 0.38
CYP2C19 P33261 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30342277 0.83 LCK (0.48) PARP1LCKDGAT1KDM4ESMN1; SMN2
SCHEMBL11555300 0.83 LCK (0.48) PARP1LCKDGAT1KDM4ESMN1; SMN2
SCHEMBL7864376 0.81 PARP1 (0.39) PLAUPARP1LCKDGAT1KDM4E
SCHEMBL1725486 0.78 HSD17B10 (0.52) PARP1LCKKDM4EGAACYP2C19
SCHEMBL29872360 0.75 KDM4E (0.59) PLAUHDAC6HDAC1HDAC3NCOR2
SCHEMBL1520940 0.75 KDM4E (0.59) PLAUHDAC6HDAC1HDAC3NCOR2
SCHEMBL1538065 0.75 GAA (0.43) PLAUHDAC6HDAC1HDAC3NCOR2
SCHEMBL1538062 0.75 GAA (0.43) PLAUHDAC6HDAC1HDAC3NCOR2
SCHEMBL2640636 0.74 HDAC6 (0.60) HDAC6PARP1HDAC1HDAC3NCOR2
SCHEMBL7864378 0.74 HSD17B10 (0.53) HDAC6HDAC1HDAC3NCOR2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 458 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117964536-A Method for preparing cyclohexylbenzene hydroperoxide by oxidizing cyclohexylbenzene 中国石油化工股份有限公司 2024-05-03 CN claimed
CN-117964537-A Process for preparing cyclohexylbenzene hydroperoxide 中国石油化工股份有限公司 2024-05-03 CN claimed
CN-114805042-A Method and system for preparing cyclopentanone and application thereof 中国石油化工股份有限公司 2022-07-29 CN claimed
CN-114805043-A Preparation method and system of cyclopentanone 中国石油化工股份有限公司 2022-07-29 CN claimed
CN-112358380-A Synthesis method of 4- (4' -alkylcyclohexyl) cyclohexanol 惠泽化学科技(濮阳)有限公司 2021-02-12 CN claimed
CN-111635287-A Synthesis method of substituted phenol 安徽中羰碳一工业技术有限责任公司 2020-09-08 CN claimed
CN-111606784-A Synthetic method of 4, 4' -dihydroxybiphenyl 安徽中羰碳一工业技术有限责任公司 2020-09-01 CN claimed
CN-117964537-A Process for preparing cyclohexylbenzene hydroperoxide 中国石油化工股份有限公司 2024-05-03 CN disclosed
CN-117964536-A Method for preparing cyclohexylbenzene hydroperoxide by oxidizing cyclohexylbenzene 中国石油化工股份有限公司 2024-05-03 CN disclosed
CN-114805042-A Method and system for preparing cyclopentanone and application thereof 中国石油化工股份有限公司 2022-07-29 CN disclosed
CN-114057620-A Method and system for preparing hydrogen peroxide cyclopentylbenzene by cyclopentene 中国石油化工股份有限公司 2022-02-18 CN disclosed
US-11213804-B2 Dehydrogenation catalysts and methods of making and using the same EXXONMOBIL CHEMICAL PATENTS INC. (US) 2022-01-04 US disclosed
CN-113698332-A Method for preparing hydrogen peroxide cyclopentylbenzene from cyclopentylbenzene 中国石油化工股份有限公司 2021-11-26 CN disclosed
US-20030083527-A1 Method for producing aromatic alcohols, especially phenol CREAVIS GESELLSCHAFT FUER TECHNOLOGY UND INNOVATION MBH (DE) 2003-05-01 US disclosed
US-6297403-B1 OXIDATION OF A (DI)ARYL METHANE OR METHYLENE DERIVATIVE IN PRESENCE OF AN AMINE OXIDE OR HYDROXYAMINE DERIVATIVE MEDIATOR; BY-PRODUCT INHIBITION Consortium für elektrochemische Industrie GmbH (DE) 2001-10-02 US disclosed
US-6242245-B1 DELIGNIFICATION BY ADDING SUSPENSION OF LACCASE, OXIDANT, MEDIATOR SUCH AS VIOLURIC ACID, AND XYLANASE TO AQUEOUS SUSPENSION OF LIGNIN MATERIAL AND MIXING; MEDIATOR DOES NOT DEACTIVATE ENZYME Consortium für elektrochemische Industrie GmbH (DE) 2001-06-05 US disclosed
US-6187170-B1 SYSTEM FOR THE ELECTROCHEMICAL CLEAVAGE OF COMPOUNDS WHICH INCLUDES A MEDIATOR AND AT LEAST TWO ELECTRODES FOR THE ELECTROCHEMICAL ACTIVATION OF THE MEDIATOR Consortium für elektrochemische Industrie GmbH (DE) 2001-02-13 US disclosed
US-6169213-B1 REACTING A HETEROARYL METHANOL WITH AN OXIDANT AND A MEDIATOR CONTAINING AMINO OXIDE GROUP TO FORM HETEROARYL ALDEHYDE OR A HETEROARYL KETONE Consortium f{umlaut over (u)}r elektrochemische Industrie GmbH (DE) 2001-01-02 US disclosed
US-6069282-A REACTION OF VINYL-, ALKYNYL- OR ARYL-METHANOLS WITH THE AID OF A MEDIATOR AND AN OXIDANT, WHEREIN THE MEDIATOR IS SELECTED FROM THE GROUP OF THE ALIPHATIC, CYCLOALIPHATIC, HETEROCYCLIC OR AROMATIC NO OR NOH CONTAINING COMPOUNDS CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 2000-05-30 US disclosed
US-6023000-A Process for the preparation of aldehydes and ketones Consortium fur elektrochemisch Industrie GmbH (DE) 2000-02-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11213804-B2 Dehydrogenation catalysts and methods of making and using the same IDH2, ADH4, IDH1 PLAU 2025/4885HDAC6 3314/4885PARP1 1670/4885
US-20030083527-A1 Method for producing aromatic alcohols, especially phenol CYP2E1, AOC2, ADH1C PLAU 4585/4885HDAC6 4679/4885PARP1 1744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.