SCHEMBL4514573

SCHEMBL4514573

COc1c(C)c(C(=O)c2ccc(N)c(C(=O)O)c2C)n2cc(OCCOCCOCCOCCOCCOCCOCCOc3ccc4c(OC)c(C)c(C(=O)c5ccc(N)c(C(=O)O)c5C)n4c3)ccc12

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PLA2G1B P04054 1/20 0.32
▸ PLA2G2A P14555 1/20 0.32
▸ RARB P10826 2/20 0.31
▸ RARA P10276 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1573145 0.84 RARB (0.34) PLA2G1BPLA2G2ARARBRARAKDM4E
SCHEMBL1573088 0.84 RARB (0.34) PLA2G1BPLA2G2ARARBRARAKDM4E
SCHEMBL4500962 0.80 HTT (0.37) KDM4EMEN1KMT2A
SCHEMBL4514569 0.80 MAPT (0.36) KDM4EKMT2A
SCHEMBL4516631 0.79 ALDH1A1 (0.36) PLA2G1BPLA2G2AKDM4EMEN1KMT2A
SCHEMBL4500669 0.77 LMNA (0.34) KDM4EMEN1KMT2A
SCHEMBL1573232 0.77 ALDH1A1 (0.33) PLA2G1BPLA2G2AKDM4EKMT2A
SCHEMBL4508201 0.75 MAPT (0.38) RARBRARAKDM4EMEN1KMT2A
SCHEMBL13918705 0.73 MAPT (0.35) KDM4EMEN1KMT2A
SCHEMBL3947583 0.72 ALDH1A1 (0.36) KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9120819-B2 FGF-receptor agonist dimeric compounds SANOFI (FR) 2015-09-01 — — US disclosed
US-20090069368-A1 FGF-RECEPTOR AGONIST DIMERIC COMPOUNDS SANOFI-AVENTIS (FR) 2009-03-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069368-A1 FGF-RECEPTOR AGONIST DIMERIC COMPOUNDS FGF2, FGFR1, FGF1 PLA2G1B 1236/4885PLA2G2A 1138/4885RARB 445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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