Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BCKDK | O14874 | 1/20 | 0.49 |
| ▸ | MPI | P34949 | 4/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.43 |
| ▸ | G6PD | P11413 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 3/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PMM2 | O15305 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31344216 | 1.00 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11574705 | 0.92 | KDM4E (0.47) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL31344125 | 0.90 | KDM4E (0.54) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11574612 | 0.90 | KDM4E (0.54) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11158837 | 0.84 | MPI (0.46) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL4732338 | 0.84 | KDM4E (0.66) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11158985 | 0.82 | G6PD (0.40) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11152570 | 0.80 | MAPT (0.39) | ALDH1A1LMNAMAPTPOLBBCKDK | |
| SCHEMBL11165497 | 0.80 | NPC1 (0.68) | ALDH1A1MAPTMPIPHOSPHO1MIF | |
| SCHEMBL4732252 | 0.80 | KDM4E (0.39) | ALDH1A1LMNAMAPTPOLBBCKDK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482344-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482344-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482344-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070088016-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2007-04-19 | — | — | US | disclosed |
| US-20070088016-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2007-04-19 | — | — | US | disclosed |
| US-20070088016-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2007-04-19 | — | — | US | disclosed |
| WO-2005066153-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005066153-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088016-A1 | Tricyclic steroid hormone nuclear receptor modulators | NR3C2, NR3C1, NR5A1 | ALDH1A1 2206/4885LMNA 2606/4885MAPT 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.