SCHEMBL451620

SCHEMBL451620

Cc1ccc(C(F)(F)C(F)(F)F)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
KIF11 P52732 2/20 0.38
CYP19A1 P11511 2/20 0.35
ESR1 P03372 3/20 0.33
HTT P42858 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MAPT P10636 2/20 0.33
TP53 P04637 1/20 0.33
MEN1 O00255 1/20 0.33
MITF O75030 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 2/20 0.32
TSHR P16473 1/20 0.32
PRSS1 P07477 1/20 0.32
PRSS2 P07478 1/20 0.32
PRSS3 P35030 1/20 0.32
LMNA P02545 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC8 Q9BY41 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16626111 0.90 ALDH1A1 (0.42) ALDH1A1KIF11CYP19A1ESR1HTT
SCHEMBL26756644 0.85 ALDH1A1 (0.39) ALDH1A1KIF11CYP19A1ESR1HTT
SCHEMBL26756584 0.83 HDAC1 (0.38) ALDH1A1KIF11CYP19A1ESR1MAPT
SCHEMBL12708541 0.82 ALDH1A1 (0.46) ALDH1A1KIF11ESR1SMN1; SMN2MAPT
SCHEMBL11746050 0.82 CYP19A1 (0.42) ALDH1A1KIF11CYP19A1ESR1MEN1
SCHEMBL13255255 0.81 PDE2A (0.41) ESR1MAPTMEN1KMT2ATSHR
SCHEMBL15957681 0.81 CYP19A1 (0.41) ALDH1A1KIF11CYP19A1ESR1SMN1; SMN2
SCHEMBL29728144 0.80 ESR1 (0.46) ALDH1A1KIF11CYP19A1ESR1MAPT
SCHEMBL13105395 0.80 ALDH1A1 (0.39) ALDH1A1KIF11CYP19A1ESR1MAPT
SCHEMBL47866 0.80 ESR1 (0.46) ALDH1A1KIF11CYP19A1ESR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2435446-B1 FLUORINATED SILYLETHYNYL PENTACENE COMPOUNDS AND COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 3M INNOVATIVE PROPERTIES CO (US) 2016-11-30 EP disclosed
US-8920679-B2 Fluorinated silylethynyl pentacene compounds and compositions and methods of making and using the same 3M INNOVATIVE PROPERTIES CO. (US) 2014-12-30 US disclosed
US-20120061620-A1 Fluorinated Silyethynyl Pentacene Compounds and Compositions and Methods of Making and Using the Same 3M INNOVATIVE PROPERTIES COMPANY 2012-03-15 US disclosed
WO-2010138807-A1 FLUORINATED SILYLETHYNYL PENTACENE COMPOUNDS AND COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 3M INNOVATIVE PROPERTIES COMPANY (US) 2010-12-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120061620-A1 Fluorinated Silyethynyl Pentacene Compounds and Compositions and Methods of Making and Using the Same PFAS, FLNB, FLNA ALDH1A1 1699/4885KIF11 2599/4885CYP19A1 945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.