Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | APP | P05067 | 9/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515563 | 0.88 | CYP3A4 (0.46) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL4513629 | 0.82 | APP (0.52) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL4498399 | 0.75 | CYP2C19 (0.42) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL4505856 | 0.74 | ALDH1A1 (0.37) | IDH2 | |
| SCHEMBL4505013 | 0.73 | CTSK (0.46) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL3684812 | 0.73 | ALDH1A1 (0.41) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL3676962 | 0.73 | CTSK (0.80) | CTSK | |
| SCHEMBL8290034 | 0.72 | CTSK (0.65) | CTSK | |
| SCHEMBL4498998 | 0.71 | CTSK (0.40) | CYP3A4APPCYP2C19CYP2C9CYP2D6 | |
| SCHEMBL4514275 | 0.71 | APP (0.52) | CYP3A4APPCYP2C19CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | claimed |
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MAOB, MAOA, XDH | CYP3A4 311/4885APP 1024/4885CYP2C19 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.