Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505158 | 0.90 | MAPT (0.64) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4496601 | 0.88 | MAPT (0.60) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4518670 | 0.85 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4509290 | 0.85 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4508426 | 0.84 | ALDH1A1 (0.56) | MAPTSMN1; SMN2RAB9AKDM4EKMT2A | |
| SCHEMBL4517237 | 0.84 | MAPT (0.61) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4503513 | 0.81 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4509030 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2SCDSCD5ALDH1A1 | |
| SCHEMBL4505147 | 0.80 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL4496073 | 0.78 | ALDH1A1 (0.54) | MAPTSMN1; SMN2RAB9AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | MAPT 4022/4885SMN1; SMN2 2075/4885NPC1 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.