Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516601 | 0.88 | MAPT (0.63) | MAPTSMN1; SMN2KDM4ENPC1GAA | |
| SCHEMBL4505158 | 0.87 | MAPT (0.64) | MAPTSMN1; SMN2KDM4ENPC1GAA | |
| SCHEMBL4508842 | 0.84 | ALDH1A1 (0.52) | MAPTSMN1; SMN2KDM4ERAB9ALMNA | |
| SCHEMBL4517237 | 0.80 | MAPT (0.61) | MAPTSMN1; SMN2KDM4ENPC1GAA | |
| SCHEMBL4508856 | 0.80 | MRGPRX4 (0.48) | MAPTKDM4EGAAFFAR1KDR | |
| SCHEMBL4512260 | 0.79 | SCD5 (0.45) | MAPTKDRMRGPRX4PLK4AURKA | |
| SCHEMBL4506513 | 0.79 | SCD5 (0.49) | MAPTSMN1; SMN2KDM4EMEN1HPGD | |
| SCHEMBL4503513 | 0.79 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2KDM4ENPC1GAA | |
| Hydrochloric Acid SCHEMBL4496489 | 0.78 | MRGPRX4 (0.47) | MAPTKDM4EGAAMEN1KMT2A | |
| SCHEMBL4518670 | 0.78 | MAPT (0.56) | MAPTSMN1; SMN2KDM4ENPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | MAPT 4022/4885SMN1; SMN2 2075/4885KDM4E 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.