Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 6/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSH | P09668 | 2/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580730 | 1.00 | ALDH1A1 (0.46) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL13223447 | 0.86 | CYP1A2 (0.47) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL10404341 | 0.85 | ALDH1A1 (0.44) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL8376755 | 0.85 | ALDH1A1 (0.44) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL14297463 | 0.84 | ALPI (0.41) | ALDH1A1ALPIPKMPTGS1XIAP | |
| SCHEMBL11110716 | 0.83 | MMP12 (0.50) | ALDH1A1CYP1A2CTSKTSHRMEN1 | |
| SCHEMBL28540100 | 0.83 | SRR (0.46) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL7296959 | 0.83 | SRR (0.46) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL14762630 | 0.83 | SRR (0.46) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL678123 | 0.82 | CTSK (0.41) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4294903-B2 | — | — | 2009-07-15 | — | — | JP | claimed |
| JP-2003519135-A | — | — | 2003-06-17 | — | — | JP | claimed |
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |
| EP-0184550-B1 | 5-AMINO-4-HYDROXY VALERYL AMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-03-18 | — | — | EP | disclosed |
| US-4931591-A | Novel 5-amino-4-hydroxyvaleryl derivatives | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | disclosed |
| EP-0126849-A1 | Pharmacologically active N-amino hydantoin derivatives, their synthesis and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-12-05 | — | — | EP | disclosed |