Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20554826 | 1.00 | MTNR1A (0.48) | MTNR1AMTNR1BHTR1ADRD2DRD1 | |
| SCHEMBL9786948 | 0.90 | MTNR1A (0.61) | MTNR1AMTNR1BHTR1ADRD2DRD1 | |
| SCHEMBL13889139 | 0.88 | HTR1A (0.49) | MTNR1AMTNR1BHTR1ADRD2DRD1 | |
| SCHEMBL4520723 | 0.86 | SCN9A (0.46) | MTNR1AMTNR1BHTR1ADRD2DRD1 | |
| SCHEMBL28356770 | 0.86 | MTNR1A (0.45) | MTNR1AMTNR1BHTR1ADRD2DRD1 | |
| SCHEMBL4505997 | 0.82 | DRD2 (0.52) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL14157823 | 0.82 | DRD2 (0.52) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL20873491 | 0.82 | MEN1 (0.46) | MAPT | |
| SCHEMBL20873473 | 0.81 | SCN9A (0.42) | MTNR1A | |
| SCHEMBL4747000 | 0.81 | SCN9A (0.42) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099187-A1 | Novel 8-Sulfonyl-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5HT6 Receptor | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099187-A1 | Novel 8-Sulfonyl-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5HT6 Receptor | HTR6, HTR1D, HTR1A | MTNR1A 130/4885MTNR1B 164/4885HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.