SCHEMBL4518592

SCHEMBL4518592

CC(C)(C)OC(=O)Nc1cccc(Nc2nc(Cl)nc(NCCc3ccc(N)cc3)n2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FCGR3B O75015 1/20 0.53
FCGR1A P12314 1/20 0.53
FCGR2A P12318 1/20 0.53
SYK P43405 1/20 0.46
CA12 O43570 4/20 0.43
CA1 P00915 4/20 0.43
CA2 P00918 4/20 0.43
CA9 Q16790 4/20 0.43
CA14 Q9ULX7 4/20 0.43
SCN9A Q15858 1/20 0.41
BRD4 O60885 1/20 0.41
CA4 P22748 1/20 0.41
CA6 P23280 1/20 0.41
CA5A P35218 1/20 0.41
CA7 P43166 1/20 0.41
CA13 Q8N1Q1 1/20 0.41
CA5B Q9Y2D0 1/20 0.41
STAT6 P42226 3/20 0.39
ITK Q08881 3/20 0.39
EGFR P00533 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4518275 0.88 FCGR3B (0.52) FCGR3BFCGR1AFCGR2ASYKBRD4
SCHEMBL13921829 0.86 FCGR3B (0.51) FCGR3BFCGR1AFCGR2ASYKBRD4
SCHEMBL4522396 0.82 SYK (0.56) SYKBRD4EGFRMETNPR3
SCHEMBL13921823 0.78 SYK (0.55) SYKCA12CA1CA2CA9
SCHEMBL2123644 0.76 BCHE (0.41) CA12CA1CA2CA9CA14
SCHEMBL21091247 0.75 MAPT (0.56) CA1CA2
SCHEMBL29660117 0.75 MAPT (0.56) CA1CA2
SCHEMBL13921831 0.74 RAB9A (0.51) SYKBRD4
SCHEMBL13921798 0.74 FCGR3B (0.84) FCGR3BFCGR1AFCGR2ASYKCA1
SCHEMBL13421360 0.74 FCGR3B (0.81) FCGR3BFCGR1AFCGR2ACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090068169-A1 2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use PROMETIC BIOSCIENCES INC. (CA) 2009-03-12 US disclosed
US-20090068169-A1 2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use PROMETIC BIOSCIENCES INC. (CA) 2009-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090068169-A1 2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use FCGR2A, FCGR3B, FCGR1A FCGR3B 2/4885FCGR1A 3/4885FCGR2A 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.