Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6780501 | 0.84 | ALDH1A1 (0.52) | GAAPOLBRAB9ACYP1A2CYP2D6 | |
| SCHEMBL4504752 | 0.83 | SMN1; SMN2 (0.50) | GAARAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30938481 | 0.80 | RAB9A (0.59) | L3MBTL1GAAPOLBRAB9ACYP2C19 | |
| SCHEMBL6036198 | 0.80 | RAB9A (0.59) | L3MBTL1GAAPOLBRAB9ACYP2C19 | |
| SCHEMBL6780237 | 0.80 | ALDH1A1 (0.46) | L3MBTL1GAAARPOLBRAB9A | |
| SCHEMBL2755850 | 0.79 | KIF11 (0.51) | DRD4IDH2RAB9ACYP1A2CYP2D6 | |
| SCHEMBL17848460 | 0.79 | POLB (0.65) | L3MBTL1GAAPOLBCYP1A2CYP2C19 | |
| SCHEMBL20560635 | 0.79 | RAB9A (0.49) | DRD4GAAIDH2ARRAB9A | |
| SCHEMBL30603334 | 0.79 | SMN1; SMN2 (0.46) | L3MBTL1GAAIDH2ARPOLB | |
| SCHEMBL1285934 | 0.79 | SMN1; SMN2 (0.46) | L3MBTL1GAAIDH2ARPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589089-B2 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20080058331-A1 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058331-A1 | Inhibitors for GlyT-1 | GLRA1, SLC1A2, AGXT | DRD4 1544/4885L3MBTL1 387/4885GAA 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.