Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519113 | 0.83 | KDM4E (0.34) | KDM4EHTTALDH1A1 | |
| SCHEMBL4511002 | 0.83 | KDM4E (0.40) | KDM4EHTTALDH1A1 | |
| SCHEMBL5015622 | 0.78 | KDM4E (0.39) | KDM4EHTTALDH1A1 | |
| SCHEMBL3060327 | 0.78 | KDM4E (0.39) | KDM4EHTTALDH1A1 | |
| SCHEMBL4506693 | 0.78 | KDM4E (0.39) | KDM4EHTTALDH1A1 | |
| SCHEMBL3056872 | 0.78 | KDM4E (0.39) | KDM4EHTTALDH1A1 | |
| SCHEMBL3052855 | 0.78 | KDM4E (0.36) | KDM4EHTTALDH1A1 | |
| SCHEMBL2305202 | 0.75 | TSHR (0.38) | KDM4EHTTALDH1A1 | |
| SCHEMBL3073265 | 0.75 | KDM4E (0.38) | KDM4EHTTALDH1A1 | |
| SCHEMBL4495894 | 0.74 | ALDH1A1 (0.39) | KDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620439-A1 | 8-pyrazinyl-S-spiropyrimidinetrione-oxazinoquinoline derivatives as antibacterial agents | PAH USA 15 LLC (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20090275536-A1 | Antibacterial Agents | PFIZER INC | 2009-11-05 | — | — | US | disclosed |
| US-7557100-B2 | Antibacterial agents | PFIZER INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1971612-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Pfizer Products Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1888597-A2 | ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20070197518-A1 | Antibacterial agents | WARNER LAMBERT COMPANY LLC | 2007-08-23 | — | — | US | disclosed |
| WO-2007072151-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| WO-2006120563-A2 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275536-A1 | Antibacterial Agents | CLPP, MRPL21, SPOUT1 | KDM4E 4288/4885HTT 3802/4885ALDH1A1 3063/4885 |
| US-20070197518-A1 | Antibacterial agents | CLPP, MRPL21, SPOUT1 | KDM4E 4288/4885HTT 3802/4885ALDH1A1 3063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.