Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.48 |
| ▸ | THRB | P10828 | 12/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PCNA | P12004 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528982 | 0.90 | THRA (0.49) | THRATHRBF2F10PPARG | |
| SCHEMBL4522420 | 0.84 | THRB (0.55) | THRATHRBTBXAS1F2F10 | |
| SCHEMBL3990206 | 0.82 | THRA (0.48) | THRATHRBF2F10PPARG | |
| SCHEMBL11070611 | 0.81 | TBXAS1 (0.63) | TBXAS1F2PPARG | |
| Hydrochloric Acid SCHEMBL11005148 | 0.81 | TBXAS1 (0.61) | TBXAS1F2PPARG | |
| SCHEMBL4513504 | 0.79 | PPARG (0.49) | THRATHRBF2F10PPARG | |
| SCHEMBL4532920 | 0.78 | THRA (0.49) | THRATHRBPPARGKDM4EALDH1A1 | |
| SCHEMBL3993120 | 0.78 | THRA (0.38) | THRATHRBPPARG | |
| SCHEMBL4351916 | 0.78 | PPARG (0.51) | THRATHRBF2F10PPARG | |
| SCHEMBL4349830 | 0.78 | THRA (0.47) | THRATHRBF2F10PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | THRA 3/4885THRB 4/4885TBXAS1 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.