Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512813 | 0.82 | ACLY (0.43) | PIK3CAAKT1MTORPIK3C3PRF1 | |
| SCHEMBL4508178 | 0.81 | PIP4K2A (0.48) | PIK3CAPIK3C3PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4511353 | 0.79 | PIK3C3 (0.52) | PIK3CAAKT1MTORPIK3C3PIK3CD | |
| SCHEMBL4506432 | 0.73 | RAB9A (0.40) | PIK3C3CYP3A4ADORA2AADORA1 | |
| SCHEMBL3972288 | 0.70 | PTGS2 (0.38) | PIK3C3PIK3CGCLK4DYRK1BCYP3A4 | |
| SCHEMBL22447465 | 0.70 | SLC22A12 (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGRORA | |
| SCHEMBL3972385 | 0.70 | ADORA2A (0.37) | PIK3C3PIK3CGDYRK1ACLK4DYRK1B | |
| SCHEMBL4506437 | 0.68 | HCRTR1 (0.33) | PIK3C3DYRK1ACYP3A4ADORA2AADORA1 | |
| SCHEMBL10369 | 0.66 | CYP1A2 (0.56) | PIK3CAPIK3CGCLK4DYRK1BCYP3A4 | |
| SCHEMBL22447437 | 0.64 | ALPL (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118336-A1 | PYRAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118336-A1 | PYRAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | MTOR, RICTOR, PIK3R5 | PIK3CA 4/4885AKT1 17/4885MTOR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.