Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525529 | 0.93 | DRD1 (0.36) | MAOAMAOBMAPK14TSHRLMNA | |
| SCHEMBL4505798 | 0.90 | HKDC1 (0.39) | SMN1; SMN2HKDC1MAOAMAOBMAPK14 | |
| SCHEMBL4526099 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2HKDC1MAOAMAOBMAPK14 | |
| SCHEMBL4519384 | 0.88 | HKDC1 (0.39) | SMN1; SMN2HKDC1MAOAMAOBMAPK14 | |
| SCHEMBL4517370 | 0.88 | GRM1 (0.37) | MAPK14MAPK1NPSR1GRM1 | |
| SCHEMBL4521828 | 0.86 | MAT2A (0.40) | SMN1; SMN2HKDC1MAOAMAOBMAPK14 | |
| SCHEMBL4519245 | 0.86 | TP53 (0.37) | MAPK14ALDH1A1LMNAMEN1MAPT | |
| SCHEMBL4522019 | 0.85 | MAPK14 (0.36) | SMN1; SMN2HKDC1MAPK14LMNAMAPT | |
| SCHEMBL4525993 | 0.84 | DRD1 (0.37) | MAOAMAOBMAPK14TSHRLMNA | |
| SCHEMBL4523638 | 0.84 | GSR (0.41) | SMN1; SMN2HKDC1MAPK14KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | BROWN REBECCA ELIZABETH | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | TRPV1, TRPV2, TRPV4 | SMN1; SMN2 3506/4885HKDC1 2603/4885MAOA 2735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.