Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | LDLR | P01130 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526064 | 0.78 | KMT2A (0.61) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL4067562 | 0.75 | ALDH1A1 (0.65) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10724023 | 0.68 | LDLR (0.62) | ALDH1A1GAALDLRHDAC6HDAC3 | |
| SCHEMBL13061385 | 0.65 | HDAC6 (0.59) | ALDH1A1GAAEPHX2NAMPTSERPINE1 | |
| SCHEMBL4519344 | 0.64 | HPGD (0.55) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL422315 | 0.64 | SERPINE1 (0.81) | ALDH1A1MEN1KMT2ANAMPTSERPINE1 | |
| SCHEMBL29838729 | 0.64 | SERPINE1 (0.81) | ALDH1A1MEN1KMT2ANAMPTSERPINE1 | |
| SCHEMBL22919723 | 0.64 | CXCR4 (0.61) | ALDH1A1MEN1KMT2AGAALDLR | |
| SCHEMBL17483890 | 0.64 | HDAC6 (0.58) | KDM4EALDH1A1MEN1KMT2AGAA | |
| SCHEMBL32669061 | 0.63 | MAPT (0.60) | KDM4EALDH1A1CYP1A2CYP3A4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | IPSEN PHARMA S.A.S. (FR) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | CNR1, CNR2, GPR18 | KDM4E 1680/4885ALDH1A1 2323/4885MEN1 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.