Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067562 | 0.86 | ALDH1A1 (0.65) | KMT2AMEN1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4520626 | 0.78 | KDM4E (0.50) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2747281 | 0.78 | KDM1A (0.55) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL16714080 | 0.77 | KMT2A (0.74) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL13789283 | 0.76 | KMT2A (1.00) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL4743665 | 0.76 | KMT2A (0.73) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL4742792 | 0.76 | KMT2A (1.00) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL13789346 | 0.76 | KMT2A (0.73) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL422315 | 0.76 | SERPINE1 (0.81) | KMT2AMEN1ALDH1A1SERPINE1HDAC8 | |
| SCHEMBL29838729 | 0.76 | SERPINE1 (0.81) | KMT2AMEN1ALDH1A1SERPINE1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | IPSEN PHARMA S.A.S. (FR) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | CNR1, CNR2, GPR18 | KMT2A 2412/4885MEN1 3878/4885NPC1 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.