SCHEMBL4520630

SCHEMBL4520630

COC(=O)c1cccnc1NC(=O)CC(C)=O

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.57
HTT P42858 2/20 0.57
CNR2 P34972 1/20 0.55
ALDH1A1 P00352 3/20 0.53
HPGD P15428 1/20 0.53
RAB9A P51151 1/20 0.53
KDM4E B2RXH2 2/20 0.50
POLB P06746 1/20 0.50
KMT2A Q03164 1/20 0.49
TDP1 Q9NUW8 1/20 0.47
PKM P14618 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MAPK10 P53779 1/20 0.45
BDKRB1 P46663 3/20 0.45
MAP2K1 Q02750 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12991853 0.87 BDKRB1 (0.57) LMNAHTTCNR2ALDH1A1HPGD
SCHEMBL12426304 0.84 CNR2 (0.60) LMNAHTTCNR2ALDH1A1HPGD
SCHEMBL24002931 0.83 HTT (0.58) HTTCNR2ALDH1A1HPGDRAB9A
SCHEMBL30305085 0.83 HTT (0.58) HTTCNR2ALDH1A1HPGDRAB9A
SCHEMBL19116336 0.83 CNR2 (0.53) LMNAHTTCNR2ALDH1A1HPGD
SCHEMBL22560798 0.83 CNR2 (0.53) LMNAHTTCNR2ALDH1A1HPGD
SCHEMBL1184896 0.83 CNR2 (0.53) HTTCNR2ALDH1A1HPGDRAB9A
SCHEMBL1169382 0.81 ALDH1A1 (0.54) LMNAHTTCNR2ALDH1A1HPGD
SCHEMBL1168814 0.79 SMN1; SMN2 (0.52) HTTCNR2ALDH1A1HPGDRAB9A
SCHEMBL20546008 0.78 KDM4E (0.58) LMNAHTTCNR2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143368-A1 Use of Cinnamoyl Compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-04 US disclosed
US-20090143368-A1 Use of Cinnamoyl Compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-04 US disclosed
EP-1857104-A1 USE OF CINNAMOYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-11-21 EP disclosed
EP-1857104-A1 USE OF CINNAMOYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143368-A1 Use of Cinnamoyl Compound COL2A1, COL1A1, SMAD2 LMNA 1153/4885HTT 4044/4885CNR2 2699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.