Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500079 | 0.78 | L3MBTL1 (0.40) | HRH3HRH4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4686868 | 0.75 | ITGB3 (0.43) | HRH3HRH4 | |
| SCHEMBL5498527 | 0.75 | L3MBTL1 (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL844472 | 0.75 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL14040614 | 0.75 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL4759546 | 0.74 | SMN1; SMN2 (0.37) | HRH3HRH4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2358938 | 0.73 | MMP12 (0.48) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL5085765 | 0.73 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL16680706 | 0.72 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL2320404 | 0.72 | FAAH (0.59) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989186-A1 | HYDANTOIN BASED KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007096259-A1 | HYDANTOIN BASED KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-30 | — | — | WO | disclosed |
| EP-1791837-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029862-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |