Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.41 |
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17956348 | 0.99 | CCNA2 (0.41) | CCNA2CDK2CCNA1NTRK1KDM4E | |
| SCHEMBL1206401 | 0.86 | MAPT (0.43) | CCNA2CDK2CCNA1NTRK1KDM4E | |
| Hydrochloric Acid SCHEMBL3457426 | 0.85 | MAPT (0.42) | CCNA2CDK2CCNA1NTRK1KDM4E | |
| SCHEMBL4522556 | 0.85 | ALDH1A1 (0.41) | LMNASMN1; SMN2RAB9AALDH1A1CYP1A2 | |
| SCHEMBL4532323 | 0.82 | KMT2A (0.42) | KDM4EKMT2ASMN1; SMN2RAB9AMEN1 | |
| SCHEMBL4522782 | 0.81 | CDK2 (0.43) | CCNA2CDK2CCNA1NTRK1KDM4E | |
| Hydrochloric Acid SCHEMBL17956349 | 0.80 | CDK2 (0.45) | CCNA2CDK2CCNA1NTRK1 | |
| SCHEMBL1205681 | 0.77 | ALDH1A1 (0.43) | CDK2NTRK1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL12879095 | 0.76 | ADORA3 (0.41) | CCNA2CDK2CCNA1NTRK1SMN1; SMN2 | |
| SCHEMBL6532636 | 0.74 | CDK2 (0.43) | CCNA2CDK2CCNA1NTRK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979356-B1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PFIZER PROD INC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20090318440-A1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PFIZER INC. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318440-A1 | CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PAK4, PAK5, PAK3 | CCNA2 1698/4885CDK2 128/4885CCNA1 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.