Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 13/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27522069 | 0.76 | ALOX15 (0.54) | ALOX15MTNR1AMTNR1BESR1AOC3 | |
| SCHEMBL24708886 | 0.75 | MTNR1B (0.62) | ALOX15TAAR1MTNR1AMTNR1BAOC3 | |
| SCHEMBL28255210 | 0.74 | ALOX15 (0.55) | ALOX15MTNR1AMTNR1B | |
| SCHEMBL12120436 | 0.72 | MTNR1A (0.50) | ALOX15TAAR1MTNR1AMTNR1BESR1 | |
| SCHEMBL27842446 | 0.71 | ALOX15 (0.56) | ALOX15MTNR1AMTNR1BESR1ALDH1A1 | |
| SCHEMBL10477183 | 0.71 | ALOX15 (0.52) | ALOX15MTNR1AMTNR1BESR1 | |
| SCHEMBL12219826 | 0.70 | MTNR1A (0.54) | ALOX15MTNR1AMTNR1BESR1AOC3 | |
| SCHEMBL12837169 | 0.70 | MTNR1A (0.54) | ALOX15MTNR1AMTNR1BESR1 | |
| SCHEMBL10477162 | 0.70 | ALOX15 (0.51) | ALOX15MTNR1AMTNR1BESR1ALDH1A1 | |
| SCHEMBL21738392 | 0.70 | MTNR1B (0.54) | ALOX15TAAR1MTNR1AMTNR1BESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560460-B2 | Substituted piperazines and methods of use | AMGEN INC. (US) | 2009-07-14 | — | — | US | claimed |
| EP-1416933-B8 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| EP-1416933-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgem, Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| WO-2003009847-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM, INC. (US) | 2003-02-06 | — | — | WO | claimed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | claimed |
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |