Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637612 | 0.75 | ALDH1A1 (0.45) | HDAC4HDAC1LMNAKDM4EALDH1A1 | |
| SCHEMBL17664006 | 0.73 | ALDH1A1 (0.42) | HDAC4HDAC1LMNAMAPTKDM4E | |
| SCHEMBL20830186 | 0.73 | ALDH1A1 (0.42) | HDAC4HDAC1LMNAMAPTKDM4E | |
| Methane SCHEMBL16742564 | 0.73 | ALDH1A1 (0.44) | HDAC4HDAC1LMNAKDM4EALDH1A1 | |
| SCHEMBL7140275 | 0.71 | ALDH1A1 (0.54) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4522155 | 0.70 | SLC9A1 (0.40) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4523501 | 0.69 | PARP1 (0.44) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL3742201 | 0.69 | ALDH1A1 (0.52) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4163540 | 0.68 | ALDH1A1 (0.68) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL31210189 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | claimed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |
| US-20090054445-A1 | Amide Substituted Quinolines | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| EP-1981882-A1 | AMIDE SUBSTITUTED QUINOLINES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007086799-A1 | AMIDE SUBSTITUTED QUINOLINES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054445-A1 | Amide Substituted Quinolines | RECQL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-0 | HDAC4 1247/4885HDAC1 503/4885LMNA 1719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.