Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PRNP | P04156 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.67 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.57 |
| ▸ | FEN1 | P39748 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484980 | 0.83 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4ELMNAHSD17B10 | |
| SCHEMBL307282 | 0.83 | ALDH1A1 (0.92) | ALDH1A1HPGDKDM4EHSD17B10SLC9A1 | |
| SCHEMBL2031645 | 0.82 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL15218337 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL7128554 | 0.81 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL12885825 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL7118702 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL4943707 | 0.80 | SLC9A1 (1.00) | SLC9A1 | |
| SCHEMBL28747774 | 0.80 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ELMNAPRNP | |
| SCHEMBL15314439 | 0.80 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ELMNASLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014206344-A1 | FUSED TRICYCLIC AMIDE COMPOUNDS AS MULTIPLE KINASE INHIBITORS | BEIGENE, LTD. (GB) | 2014-12-31 | — | — | WO | disclosed |
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-10 | — | — | US | disclosed |
| EP-1782811-A1 | NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1669348-A1 | NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 2006-06-14 | — | — | EP | disclosed |
| US-5214042-A | Use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5118708-A | USE OF 5-PHENYL-2-FURAN ESTERS, AMIDES AND KETONES AS NEUROPROTECTIVE AGENTS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-5023272-A | Use of 5-phenyl-2-furan esters and amides as antiepileptic agents | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0404231-A1 | The use of 5-phenyl-2 furan esters and amides as antiepileptic agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0404233-A2 | Novel use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227799-A1 | Novel Antimalarial Agent Containing Heterocyclic Compound | XPO1, THPO, G6PD | ALDH1A1 1926/4885HPGD 1490/4885KDM4E 3022/4885 |
| US-20070105943-A1 | Novel antifungal agent containing heterocyclic compound | ERG28, DPM1, CYP51A1 | ALDH1A1 1459/4885HPGD 2725/4885KDM4E 3245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.