Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393258 | 0.86 | PIN1 (0.51) | PIN1POLBNPSR1MMP8MAPT | |
| SCHEMBL19183403 | 0.84 | MAPT (0.49) | NPSR1MAPTTSHRKMT2ALMNA | |
| SCHEMBL5010275 | 0.84 | PIN1 (0.53) | PIN1POLBNPSR1MMP8MAPT | |
| SCHEMBL1172441 | 0.84 | PIN1 (0.53) | PIN1POLBNPSR1MMP8MAPT | |
| SCHEMBL31619474 | 0.83 | TSHR (0.58) | NPSR1MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL27502753 | 0.83 | POLB (0.52) | PIN1POLBNPSR1MMP8MAPT | |
| SCHEMBL31619451 | 0.83 | CES2 (0.47) | POLBNPSR1MMP8MAPTTHRB | |
| SCHEMBL5816392 | 0.82 | POLB (0.55) | PIN1POLBNPSR1MMP8MAPT | |
| SCHEMBL29156932 | 0.81 | CHRM2 (0.64) | PIN1POLBNPSR1MMP8ALDH1A1 | |
| SCHEMBL2910521 | 0.81 | PIN1 (0.54) | PIN1POLBNPSR1MMP8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018115380-A1 | NOVEL BENZYLAMINO SUBSTITUTED QUINAZOLINES AND DERIVATIVES AS SOS1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-28 | — | — | WO | disclosed |
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | NEUROSEARCH A/S (DK) | 2009-11-26 | — | — | US | disclosed |
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | NEUROSEARCH A/S (DK) | 2009-11-26 | — | — | US | disclosed |
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | NEUROSEARCH A/S (DK) | 2009-11-26 | — | — | US | disclosed |
| EP-1951685-A1 | NOVEL QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007057447-A1 | NOVEL QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-05-24 | — | — | WO | disclosed |
| US-5003074-A | N-fluorinated sulfonamides | CIBA-GEIGY CORPORATION (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0311086-A1 | N-fluorinated sulfon amides, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1989-04-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | KCNA7, KCNN3, KCNQ5 | PIN1 2549/4885POLB 4391/4885NPSR1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.