SCHEMBL4527982

SCHEMBL4527982

O=C(O)CC(=O)Oc1ncccc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 16/20 0.44
SSTR1 P30872 3/20 0.43
TRPV1 Q8NER1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4527979 0.92 SSTR4 (0.46) SSTR4SSTR1TRPV1
SCHEMBL27853596 0.83 SSTR4 (0.43) SSTR4SSTR1
SCHEMBL5709212 0.83 TRPV1 (0.43) SSTR4SSTR1TRPV1
SCHEMBL27725726 0.81 SSTR4 (0.43) SSTR4SSTR1
SCHEMBL4537897 0.80 L3MBTL1 (0.43) SSTR4
SCHEMBL20797342 0.80 SSTR4 (0.46) SSTR4SSTR1
SCHEMBL5709016 0.79 SLC22A12 (0.47) SSTR4SSTR1
SCHEMBL4947195 0.78 SSTR4 (0.44) SSTR4SSTR1TRPV1
SCHEMBL2635568 0.78 KIF11 (0.42) SSTR4SSTR1TRPV1
SCHEMBL4538158 0.77 MAPK8 (0.43) SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8258136-B2 Pyridazine compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-09-04 US disclosed
US-20090275589-A1 Pyridazine Compound and Use Thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-11-05 US disclosed
EP-1958946-A1 PYRIDAZINE COMPOUND AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2008-08-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090275589-A1 Pyridazine Compound and Use Thereof PLPBP, PNPO, PDXK SSTR4 4327/4885SSTR1 4348/4885TRPV1 2363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.