Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29416237 | 0.85 | IMPDH2 (0.42) | DYRK1AKDM4EHTTPIM1HASPIN | |
| SCHEMBL19469855 | 0.85 | IMPDH2 (0.42) | DYRK1AKDM4EHTTPIM1HASPIN | |
| SCHEMBL672509 | 0.78 | CLK1 (0.54) | MAPK10DYRK1ACLK1HIPK2TNF | |
| SCHEMBL29569821 | 0.78 | CLK1 (0.54) | MAPK10DYRK1ACLK1HIPK2TNF | |
| SCHEMBL492397 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL3810977 | 0.74 | PIM1 (0.36) | POLBPIM1HASPINMAOACDK9 | |
| SCHEMBL8763443 | 0.74 | ALDH1A1 (0.52) | KDM4EMAOA | |
| SCHEMBL28675683 | 0.74 | — | — | |
| SCHEMBL381051 | 0.73 | — | — | |
| P-Xylene SCHEMBL1420125 | 0.73 | ACHE (0.46) | MAPK10DYRK1ACLK1HIPK2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355221-A1 | Targeting the Non-Canonical NFkB Pathway in Cancer Immunotherapy | THE GENERAL HOSPITAL CORPORATION | 2021-11-18 | — | — | US | claimed |
| WO-2020082016-A1 | TARGETING THE NON-CANONICAL NFKB PATHWAY IN CANCER IMMUNOTHERAPY | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-23 | — | — | WO | claimed |
| EP-3431493-A1 | COMPOSITIONS AND METHODS FOR INDUCING SENESCENCE IN CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-01-23 | — | — | EP | claimed |
| US-20180251763-A1 | Compositions and Methods for Inducing Senescence in Cancer Cells | Université Côte d'Azur (FR) | 2018-09-06 | — | — | US | claimed |
| EP-2336315-B1 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION AS (DK) | 2017-07-19 | — | — | EP | claimed |
| US-20160208249-A1 | Compositions and Methods for Inducing Senescence in Cancer Cells | CENTRE HOPITALIER UNIVERSITAIRE DE NICE (FR) | 2016-07-21 | — | — | US | claimed |
| EP-3041859-A2 | COMPOSITIONS AND METHODS FOR INDUCING SENESCENCE IN CANCER CELLS | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2016-07-13 | — | — | EP | claimed |
| WO-2015032800-A2 | COMPOSITIONS AND METHODS FOR INDUCING SENESCENCE IN CANCER CELLS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2015-03-12 | — | — | WO | claimed |
| EP-2336315-A2 | Enzymatic encoding methods for efficient synthesis of large libraries | Nuevolution A/S (DK) | 2011-06-22 | — | — | EP | claimed |
| EP-0215445-B1 | PYRAZOLOISOQUINOLINE DERIVATIVES, A PROCESS FOR PREPARATION THEREOF AND A PLANT GROWTH REGULATING COMPOSITION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | claimed |
| US-4751226-A | Pyrazoloisoquinoline derivatives, plant growth regulating compositions, and method of use therefor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-14 | — | — | US | claimed |
| EP-0215445-A2 | Pyrazoloisoquinoline derivatives, a process for preparation thereof and a plant growth regulating composition | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-25 | — | — | EP | claimed |
| JP-62149676-A | — | — | None | — | — | JP | disclosed |
| US-20240415801-A1 | Methods and Compositions for Treating Fibroids | LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER | 2024-12-19 | — | — | US | disclosed |
| US-11702652-B2 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION A/S (DK) | 2023-07-18 | — | — | US | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| JP-S62149676-A | PYRAZOLOISOQUINOLINE DERIVATIVE, PRODUCTION THEREOF AND AGRICULTURAL CHEMICAL | FUJISAWA PHARMACEUT CO LTD | 1987-07-03 | — | — | JP | disclosed |
| EP-0215445-A2 | Pyrazoloisoquinoline derivatives, a process for preparation thereof and a plant growth regulating composition | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-25 | — | — | EP | disclosed |
| EP-0215445-A2 | Pyrazoloisoquinoline derivatives, a process for preparation thereof and a plant growth regulating composition | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-25 | — | — | EP | disclosed |
| EP-0215445-A2 | Pyrazoloisoquinoline derivatives, a process for preparation thereof and a plant growth regulating composition | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-25 | — | — | EP | disclosed |