Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5913154 | 0.98 | GAA (0.65) | GAAHTR7ALDH1A1CYP3A4HTR1A | |
| SCHEMBL30833064 | 0.85 | ALDH1A1 (0.67) | GAAHTR7ALDH1A1CYP3A4HTR1A | |
| SCHEMBL1961585 | 0.85 | ALDH1A1 (0.67) | GAAHTR7ALDH1A1CYP3A4HTR1A | |
| Hydrochloric Acid SCHEMBL27621161 | 0.84 | ALDH1A1 (0.65) | GAAHTR7ALDH1A1CYP3A4HTR1A | |
| SCHEMBL5675706 | 0.82 | HTR7 (0.64) | HTR7ALDH1A1CYP3A4HTR1AHTR1D | |
| SCHEMBL3716351 | 0.82 | GAA (0.62) | GAAHTR7ALDH1A1CYP3A4HTR1A | |
| SCHEMBL5913873 | 0.82 | HSD17B10 (0.50) | GAAHTR7ALDH1A1MEN1MAPT | |
| Hydrochloric Acid SCHEMBL5913770 | 0.81 | USP2 (0.49) | GAAHTR7ALDH1A1MEN1MAPT | |
| SCHEMBL3720231 | 0.80 | GAA (0.56) | GAAALDH1A1CYP3A4MEN1MAPT | |
| Hydrochloric Acid SCHEMBL5913692 | 0.80 | GAA (0.44) | GAAHTR7ALDH1A1HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103517903-B | Pyrrolopyridine aminoderivative as MPS1 inhibitor | 癌症研究科技有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-103517903-A | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER REC TECH LTD | 2014-01-15 | — | — | CN | disclosed |
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
| CN-101291924-A | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORP (US) | 2008-10-22 | — | — | CN | disclosed |
| EP-1802608-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040526-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | GAA 3392/4885HTR7 606/4885ALDH1A1 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.