Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4531554 | 0.88 | ALDH1A1 (0.48) | ALDH1A1HPGDLMNAGAAKMT2A | |
| SCHEMBL4764325 | 0.84 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL4521261 | 0.77 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL4518839 | 0.76 | SMN1; SMN2 (0.47) | ALDH1A1HPGDGAAKMT2AKDM4E | |
| SCHEMBL4891790 | 0.74 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL29832095 | 0.72 | ALDH1A1 (0.41) | ALDH1A1HPGDLMNAGAAKMT2A | |
| SCHEMBL4218652 | 0.72 | KDM4E (0.71) | L3MBTL1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL28800164 | 0.70 | PDE4B (0.55) | ALDH1A1HPGDLMNAGAAKMT2A | |
| SCHEMBL4520363 | 0.70 | ALDH1A1 (0.53) | L3MBTL1ALDH1A1HPGDLMNAGAA | |
| SCHEMBL4523252 | 0.70 | HTT (0.52) | ALDH1A1HPGDLMNAGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498334-B2 | Pyrrolopyrimidines as phosphodiesterase VII inhibitors | MERCK PATENT GMBH (DE) | 2009-03-03 | — | — | US | disclosed |
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | MERCK PATENT GESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059686-A1 | Pyrrolopyrimidines as phosphodiesterase vII inhibitors | PDE5A, PDE3B, PDE4A | L3MBTL1 2407/4885ALDH1A1 1713/4885HPGD 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.