Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396777 | 0.95 | TDP1 (0.73) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL17396705 | 0.93 | TDP1 (0.71) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL7761107 | 0.89 | TDP1 (0.63) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL5341985 | 0.85 | TDP1 (0.54) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL7297769 | 0.84 | TDP1 (0.72) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL223441 | 0.83 | TDP1 (1.00) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL416566 | 0.83 | TDP1 (0.91) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL10436613 | 0.83 | RAB9A (0.51) | TDP1LMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14151507 | 0.83 | TDP1 (0.70) | TDP1LMNAALDH1A1MAPK1HIF1A | |
| SCHEMBL223238 | 0.81 | TDP1 (0.96) | TDP1LMNAALDH1A1MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106810444-B | A kind of method of chlorobenzoyl chloride and halogenated alkane reaction generation ester | 中国科学院大连化学物理研究所 | 2018-09-04 | — | — | CN | disclosed |
| CN-106810444-A | A kind of method of chlorobenzoyl chloride and halogenated alkane reaction generation ester | 中国科学院大连化学物理研究所 | 2017-06-09 | — | — | CN | disclosed |
| CN-103842329-B | Optical directional material | 罗利克有限公司 | 2016-12-07 | — | — | CN | disclosed |
| US-20090233948-A1 | Inhibitors of nucleoside phosphorylases and nucleosidases | NATIONAL INSTITUTES OF HEALTH | 2009-09-17 | — | — | US | disclosed |
| US-20090233948-A1 | Inhibitors of nucleoside phosphorylases and nucleosidases | NATIONAL INSTITUTES OF HEALTH | 2009-09-17 | — | — | US | disclosed |
| EP-1881984-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006123953-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-11-23 | — | — | WO | disclosed |
| EP-0972776-B1 | A phosphine sulfide, a manufacturing process therefor and a use thereof | MITSUI CHEMICALS INC (JP) | 2003-04-23 | — | — | EP | disclosed |
| US-6153794-A | Phosphine sulfide, a manufacturing process therefor and use thereof | MITSUI CHEMICALS, INC. (JP) | 2000-11-28 | — | — | US | disclosed |
| CN-1262276-A | Phosphine sulfide preparing process and use thereof | MITSUI CHEMICALS INC (JP) | 2000-08-09 | — | — | CN | disclosed |
| EP-0972776-A1 | A phosphine sulfide, a manufacturing process therefor and a use thereof | Mitsui Chemicals, Inc. (JP) | 2000-01-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233948-A1 | Inhibitors of nucleoside phosphorylases and nucleosidases | PNP, MTAP, TYMP | TDP1 193/4885LMNA 1754/4885ALDH1A1 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.