Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RBP4 | P02753 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537737 | 0.94 | KMT2A (0.60) | MEN1KMT2ARBP4CYP2D6CYP2C19 | |
| SCHEMBL4541042 | 0.86 | FAAH (0.53) | MEN1KMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL4537217 | 0.84 | BRD4 (0.55) | LMNAHTTSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4539333 | 0.81 | KMT2A (0.56) | MEN1KMT2ALMNASMN1; SMN2GRIN2B | |
| SCHEMBL4535612 | 0.80 | FAAH (0.58) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL4531019 | 0.79 | EPHX1 (0.58) | MEN1KMT2AGRIN2B | |
| SCHEMBL4542474 | 0.79 | USP30 (0.58) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL4542442 | 0.77 | BRD4 (0.44) | KMT2ALMNAMAPK1SMN1; SMN2POLB | |
| SCHEMBL4537103 | 0.76 | KDM4E (0.54) | MEN1KMT2ACYP2C19LMNAHTT | |
| SCHEMBL4535122 | 0.76 | KMT2A (0.60) | MEN1KMT2ASMN1; SMN2GRIN2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |