Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535122 | 0.95 | KMT2A (0.60) | KMT2AMEN1GRIN2BNPSR1HDAC3 | |
| SCHEMBL4537217 | 0.88 | BRD4 (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4542442 | 0.83 | BRD4 (0.44) | KMT2APOLBEPHX2ALDH1A1BRD4 | |
| SCHEMBL4541042 | 0.82 | FAAH (0.53) | KMT2AMEN1GAAEPHX2ALDH1A1 | |
| SCHEMBL4542312 | 0.81 | EPHX2 (0.61) | EPHX2 | |
| SCHEMBL4531024 | 0.81 | MEN1 (0.55) | KMT2AMEN1GRIN2BPOLBGAA | |
| SCHEMBL4537103 | 0.80 | KDM4E (0.54) | KMT2AMEN1POLBGAAALDH1A1 | |
| SCHEMBL4535571 | 0.80 | LMNA (0.40) | KMT2AMEN1EPHX2BRD4LMNA | |
| SCHEMBL4542474 | 0.77 | USP30 (0.58) | KMT2AMEN1EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4531270 | 0.77 | EPHX2 (0.68) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |