Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539333 | 0.88 | KMT2A (0.56) | BRD4EPHX1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL4541042 | 0.85 | FAAH (0.53) | BRD4SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL4542442 | 0.84 | BRD4 (0.44) | BRD4EPHX1SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4531024 | 0.84 | MEN1 (0.55) | SMN1; SMN2KDM4EGAAMAPTHTT | |
| SCHEMBL4535122 | 0.83 | KMT2A (0.60) | BRD4EPHX1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4537103 | 0.81 | KDM4E (0.54) | EPHX1ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL4542474 | 0.80 | USP30 (0.58) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL4535612 | 0.79 | FAAH (0.58) | BRD4EPHX1SMN1; SMN2NPC1TP53 | |
| SCHEMBL4535571 | 0.78 | LMNA (0.40) | BRD4TP53MAPTTDP1HTT | |
| SCHEMBL4541265 | 0.77 | BRD4 (0.48) | BRD4EPHX1SMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |