Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097218 | 0.82 | POLB (0.55) | POLBCXCR4GRIN2BBCHEACHE | |
| SCHEMBL1098879 | 0.82 | POLB (0.55) | POLBCXCR4GRIN2BBCHEACHE | |
| SCHEMBL561018 | 0.80 | CYP19A1 (0.48) | POLBKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL1099162 | 0.79 | ALDH1A1 (0.61) | POLBCXCR4GRIN2BBCHEACHE | |
| SCHEMBL4531997 | 0.77 | POLB (0.86) | POLBGRIN2BBCHEACHEBACE1 | |
| SCHEMBL4526961 | 0.76 | NPBWR1 (0.50) | POLBCXCR4GRIN2BBCHEACHE | |
| SCHEMBL716259 | 0.76 | CYP19A1 (0.54) | POLBKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL28181000 | 0.76 | BCHE (0.66) | POLBGRIN2BBCHEACHEBACE1 | |
| SCHEMBL18407603 | 0.73 | TSHR (0.56) | POLBKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL30319435 | 0.73 | TSHR (0.56) | POLBKMT2ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | POLB 2260/4885CXCR4 36/4885GRIN2B 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.